Julien's Auctions announced Tuesday that King's black Gibson ES-345 prototype guitar is among the items from his estate that will go up for bids on Sep 21.
Julien's says Gibson gave King the instrument for his 80th birthday.
The headstock has 'B.B. King 80' and a crown inlaid with mother-of-pearl.
The guitar is estimated to be worth $80,000 to $100,000.
The National Medal of Arts that President George HW Bush presented to King in 1990 is also up for auction.
So are his touring van, jewellery and clothing.
The 15-time Grammy winner was 89 years old when he died in 2015.
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